Thursday Night Football will be the backdrop for the final preseason tune-up for the San Francisco 49ers and Houston Texans. The visiting 49ers enter as 3.5-point favorites as both teams are expected to run their starters out to begin the game.
Both teams won’t begin the regular season until September 11. Find out where my best bet lies in our free NFL picks and predictions for 49ers vs. Texans on August 25.